Electro-optics and Microelectronics Seminar
Speaker: Dr. Dekel Rosenfeld
Affiliation: Bioelectronics Group,
Research Lab of Electronics (RLE)
Magnetothermal stimulation of organ function in vivo
Bioelectronics is an emerging field aiming to use electrically controlled, rather than pharmacological, stimuli to trigger cells and organs in the body. In my talk I will present an emerging approach in bioelectronics – magnetothermal stimulation for wireless control of electroactive cells, which relies on a combination of magnetic nanoparticles (MNPs) and alternating magnetic fields (AMFs).
Magnetic nanoparticles dissipate heat upon exposure to alternating magnetic fields, which can trigger thermally-sensitive ion channels and evoke membrane depolarization and changes in cell activity. In mammals, peripheral nerve fibers express heat-sensitive sodium (Na+) and calcium (Ca2+) ion channels from the transient receptor potential family. Consequently, local heating from magnetic nanoparticles can be converted into an electrochemical gradient across the neural membranes, leading to depolarization and firing of action potentials in response to the externally applied alternating magnetic fields. The use of magnetic nanoparticles eliminates the need for invasive and tissue-damaging electrodes. While other studies are using this approach for cancer hyperthermia or for deep brain stimulation, in this project the approach is translated to remote control of peripheral organ function.